With advances in information communication technologies (ICTs), social media platforms provide expanding mechanisms for understanding individuals’ contexts and behaviors. Furthermore, it can enhance overall effectiveness of health promotion and behavior change interventions by encouraging social interactions within interventions, promoting social support, and facilitating the adoption of social norm approaches. During this session, AI-fluence will share how they are using Artificial Intelligence to identify nano and micro-influencers on existing social media platforms (Facebook, Instagram, Twitter, Tiktok) to lead social behavior change (SBC) campaigns. Macro-Eyes will share their experiences using AI/ML and social media to predict hyper local vaccine hesitancy and target behavioral interventions among hesitant communities. PSI will share how they are using Facebook to drive SBC on COVID-19 prevention and vaccines globally.